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Title:

Spatial Distribution of Immune Cells in Head and Neck Squamous Cell Carcinomas.

Document type:
Journal Article
Author(s):
Idel, Christian; Ribbat-Idel, Julika; Klapper, Luise; Krupar, Rosemarie; Bruchhage, Karl-Ludwig; Dreyer, Eva; Rades, Dirk; Polasky, Christina; Offermann, Anne; Kirfel, Jutta; Perner, Sven; Wollenberg, Barbara
Abstract:
BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) have a very moderate response rate to immune checkpoint inhibitor (ICI) treatment compared to other cancer types. Lacking predictive markers for treatment response, we analyzed the immune status of HNSCC and assessed the spatial distribution of immune cells. MATERIALS AND METHODS: Via assessing hematoxylin-eosin (H&E;) stains, we divided HNSCCs by the immune cell distribution in hot, cold, and excluded tumors. For each group, each with 10...     »
Journal title abbreviation:
Front Oncol
Year:
2021
Journal volume:
11
Fulltext / DOI:
doi:10.3389/fonc.2021.712788
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34778030
Print-ISSN:
2234-943X
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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