Combination of Sorafenib and Transarterial Chemoembolization in Selected Patients with Advanced-Stage Hepatocellular Carcinoma: A Retrospective Cohort Study at Three German Liver Centers.

Koch, Christine; Göller, Markus; Schott, Eckart; Waidmann, Oliver; Op den Winkel, Mark; Paprottka, Philipp; Zangos, Stephan; Vogl, Thomas; Bechstein, Wolf Otto; Zeuzem, Stefan; Kolligs, Frank T; Trojan, Jörg

doi:10.3390/cancers13092121

2021

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Title:: Combination of Sorafenib and Transarterial Chemoembolization in Selected Patients with Advanced-Stage Hepatocellular Carcinoma: A Retrospective Cohort Study at Three German Liver Centers.
Document type:: Journal Article
Author(s):: Koch, Christine; Göller, Markus; Schott, Eckart; Waidmann, Oliver; Op den Winkel, Mark; Paprottka, Philipp; Zangos, Stephan; Vogl, Thomas; Bechstein, Wolf Otto; Zeuzem, Stefan; Kolligs, Frank T; Trojan, Jörg
Abstract:: BACKGROUND AND AIMS: Systemic treatment with sorafenib has been the standard of care (SOC) in patients with advanced Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) for more than a decade. TACE has been reported to allow better local tumor control in selected patients with BCLC stage C HCC. METHODS: A retrospective analysis of patients with BCLC stage C HCC that were treated with sorafenib and TACE was conducted; they were compared to BCLC stage C patients treated either with TACE or sorafenib in the same period of time outside a clinical trial. RESULTS: A total of 201 patients with BCLC stage C were identified, who were treated with either sorafenib and TACE (group A; n = 54), sorafenib (group B; n = 82) or TACE (group C; n = 65). No significant difference in baseline characteristics was observed. Time to progression was 7.0 months (95% CI: 4.3-9.7), 4.1 months (95% CI: 3.6-4.7) and 5.0 months (95% CI: 2.9-7.1) in groups A, B and C, respectively, and overall survival was 16.5 months (95% CI: 15.0-18.1), 8.4 months (95% CI: 6.0-10.8) and 10.5 months (95% CI: 7.5-13.6), respectively (group A vs. group B: p < 0.001; group A vs. group C: p = 0.0023). Adverse events of grade 3/4 occurred in 34% of patients in group A. CONCLUSIONS: Although sorafenib is a SOC in patients with BCLC stage C HCC, TACE is frequently used as an additional locoregional treatment in selected patients. This combined approach resulted in a significant overall survival benefit in selected patients, although randomized trials have not yet proven this benefit.
Journal title abbreviation:: Cancers (Basel)
Year:: 2021
Journal volume:: 13
Journal issue:: 9
Fulltext / DOI:: doi:10.3390/cancers13092121
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/33924810
TUM Institution:: Professur für Interventionelle Radiologie (Prof. Paprottka)
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mediaTUM Gesamtbestand Hochschulbibliographie 2021 Fakultäten Medizin Institut für Radiologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Professur für Interventionelle Radiologie (Prof. Paprottka)2021