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Titel:

The CGRP receptor component RAMP1 links sensory innervation with YAP activity in the regenerating liver.

Dokumenttyp:
Journal Article
Autor(en):
Laschinger, Melanie; Wang, Yang; Holzmann, Gabriela; Wang, Baocai; Stöß, Christian; Lu, Miao; Brugger, Marcus; Schneider, Annika; Knolle, Percy; Wohlleber, Dirk; Schulze, Sarah; Steiger, Katja; Tsujikawa, Kazutake; Altmayr, Felicitas; Friess, Helmut; Hartmann, Daniel; Hüser, Norbert; Holzmann, Bernhard
Abstract:
The effectiveness of liver regeneration limits surgical therapies of hepatic disorders and determines patient outcome. Here, we investigated the role of the neuropeptide calcitonin gene-related peptide (CGRP) for liver regeneration after acute or chronic injury. Mice deficient for the CGRP receptor component receptor activity-modifying protein 1 (RAMP1) were subjected to a 70% partial hepatectomy or repeated intraperitoneal injections of carbon tetrachloride. RAMP1 deficiency severely impaired r...     »
Zeitschriftentitel:
FASEB J
Jahr:
2020
Band / Volume:
34
Heft / Issue:
6
Seitenangaben Beitrag:
8125-8138
Volltext / DOI:
doi:10.1096/fj.201903200R
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32329113
Print-ISSN:
0892-6638
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Roman Herzog Comprehensive Cancer Center
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