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Title:

Repositioning TH cell polarization from single cytokines to complex help.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Author(s):
Tuzlak, Selma; Dejean, Anne S; Iannacone, Matteo; Quintana, Francisco J; Waisman, Ari; Ginhoux, Florent; Korn, Thomas; Becher, Burkhard
Abstract:
When helper T (TH) cell polarization was initially described three decades ago, the TH cell universe grew dramatically. New subsets were described based on their expression of few specific cytokines. Beyond TH1 and TH2 cells, this led to the coining of various TH17 and regulatory (Treg) cell subsets as well as TH22, TH25, follicular helper (TFH), TH3, TH5 and TH9 cells. High-dimensional single-cell analysis revealed that a categorization of TH cells into a single-cytokine-based nomenclature fail...     »
Journal title abbreviation:
Nat Immunol
Year:
2021
Journal volume:
22
Journal issue:
10
Pages contribution:
1210-1217
Fulltext / DOI:
doi:10.1038/s41590-021-01009-w
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34545250
Print-ISSN:
1529-2908
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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