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Titel:

Anti-CD20 Depletes Meningeal B Cells but Does Not Halt the Formation of Meningeal Ectopic Lymphoid Tissue.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Brand, Rosa Margareta; Friedrich, Verena; Diddens, Jolien; Pfaller, Monika; Romana de Franchis, Francesca; Radbruch, Helena; Hemmer, Bernhard; Steiger, Katja; Lehmann-Horn, Klaus
Abstract:
OBJECTIVE: To investigate whether anti-CD20 B-cell-depleting monoclonal antibodies (ɑCD20 mAbs) inhibit the formation or retention of meningeal ectopic lymphoid tissue (mELT) in a murine model of multiple sclerosis (MS). METHODS: We used a spontaneous chronic experimental autoimmune encephalomyelitis (EAE) model of mice with mutant T-cell and B-cell receptors specific for myelin oligodendrocyte glycoprotein (MOG), which develop meningeal inflammatory infiltrates resembling those described in MS....     »
Zeitschriftentitel:
Neurol Neuroimmunol Neuroinflamm
Jahr:
2021
Band / Volume:
8
Heft / Issue:
4
Volltext / DOI:
doi:10.1212/NXI.0000000000001012
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34021057
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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