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Title:

Inceptor counteracts insulin signalling in β-cells to control glycaemia.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ansarullah; Jain, Chirag; Far, Fataneh Fathi; Homberg, Sarah; Wißmiller, Katharina; von Hahn, Felizitas Gräfin; Raducanu, Aurelia; Schirge, Silvia; Sterr, Michael; Bilekova, Sara; Siehler, Johanna; Wiener, Julius; Oppenländer, Lena; Morshedi, Amir; Bastidas-Ponce, Aimée; Collden, Gustav; Irmler, Martin; Beckers, Johannes; Feuchtinger, Annette; Grzybek, Michal; Ahlbrecht, Christin; Feederle, Regina; Plettenburg, Oliver; Müller, Timo D; Meier, Matthias; Tschöp, Matthias H; Coskun, Ünal; Lickert, H...     »
Abstract:
Resistance to insulin and insulin-like growth factor 1 (IGF1) in pancreatic β-cells causes overt diabetes in mice; thus, therapies that sensitize β-cells to insulin may protect patients with diabetes against β-cell failure1-3. Here we identify an inhibitor of insulin receptor (INSR) and IGF1 receptor (IGF1R) signalling in mouse β-cells, which we name the insulin inhibitory receptor (inceptor; encoded by the gene Iir). Inceptor contains an extracellular cysteine-rich domain with similarities to...     »
Journal title abbreviation:
Nature
Year:
2021
Journal volume:
590
Journal issue:
7845
Pages contribution:
326-331
Fulltext / DOI:
doi:10.1038/s41586-021-03225-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33505018
Print-ISSN:
0028-0836
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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