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Title:

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.

Document type:
Journal Article
Author(s):
Novikoff, Aaron; O'Brien, Shannon L; Bernecker, Miriam; Grandl, Gerald; Kleinert, Maximilian; Knerr, Patrick J; Stemmer, Kerstin; Klingenspor, Martin; Zeigerer, Anja; DiMarchi, Richard; Tschöp, Matthias H; Finan, Brian; Calebiro, Davide; Müller, Timo D
Abstract:
OBJECTIVE: We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including semaglutide, and GLP-1/GIP dual-agonists MAR709 and tirzepatide. METHODS: Receptor G protein recruitment and internalization/trafficking dynamics were assessed using bioluminescence resonance energy transfer (BRET)-based technology and live-cell HILO microscopy. RESULTS: Relative to native and acylated GLP-1 agonists, MAR709 and tir...     »
Journal title abbreviation:
Mol Metab
Year:
2021
Journal volume:
49
Fulltext / DOI:
doi:10.1016/j.molmet.2021.101181
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33556643
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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