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Title:

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.

Document type:
Journal Article
Author(s):
Zhang, Qian; Delessa, Challa Tenagne; Augustin, Robert; Bakhti, Mostafa; Colldén, Gustav; Drucker, Daniel J; Feuchtinger, Annette; Caceres, Cristina Garcia; Grandl, Gerald; Harger, Alexandra; Herzig, Stephan; Hofmann, Susanna; Holleman, Cassie Lynn; Jastroch, Martin; Keipert, Susanne; Kleinert, Maximilian; Knerr, Patrick J; Kulaj, Konxhe; Legutko, Beata; Lickert, Heiko; Liu, Xue; Luippold, Gerd; Lutter, Dominik; Malogajski, Emilija; Medina, Marta Tarquis; Mowery, Stephanie A; Blutke, Andreas; Pe...     »
Abstract:
Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR) should be activated or inhibited for the treatment of obesity. Gipr was recently demonstrated in hypothalamic feeding centers, but the physiological relevance of CNS Gipr remains unknown. Here we show that HFD-fed CNS-Gipr KO mice and humanized (h)GIPR knockin mice with CNS-hGIPR deletion show decreased body weight and improved glucose metabolism. In DIO mice, acute central and peripheral administra...     »
Journal title abbreviation:
Cell Metab
Year:
2021
Journal volume:
33
Journal issue:
4
Pages contribution:
833-844.e5
Fulltext / DOI:
doi:10.1016/j.cmet.2021.01.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33571454
Print-ISSN:
1550-4131
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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