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Titel:

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Aliluev, Alexandra; Tritschler, Sophie; Sterr, Michael; Oppenländer, Lena; Hinterdobler, Julia; Greisle, Tobias; Irmler, Martin; Beckers, Johannes; Sun, Na; Walch, Axel; Stemmer, Kerstin; Kindt, Alida; Krumsiek, Jan; Tschöp, Matthias H; Luecken, Malte D; Theis, Fabian J; Lickert, Heiko; Böttcher, Anika
Abstract:
Excess nutrient uptake and altered hormone secretion in the gut contribute to a systemic energy imbalance, which causes obesity and an increased risk of type 2 diabetes and colorectal cancer. This functional maladaptation is thought to emerge at the level of the intestinal stem cells (ISCs). However, it is not clear how an obesogenic diet affects ISC identity and fate. Here we show that an obesogenic diet induces ISC and progenitor hyperproliferation, enhances ISC differentiation and cell turnov...     »
Zeitschriftentitel:
Nat Metab
Jahr:
2021
Band / Volume:
3
Heft / Issue:
9
Seitenangaben Beitrag:
1202-1216
Volltext / DOI:
doi:10.1038/s42255-021-00458-9
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34552271
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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