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Titel:

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.

Dokumenttyp:
Journal Article
Autor(en):
Zhang, Qian; Delessa, Challa Tenagne; Augustin, Robert; Bakhti, Mostafa; Colldén, Gustav; Drucker, Daniel J; Feuchtinger, Annette; Caceres, Cristina Garcia; Grandl, Gerald; Harger, Alexandra; Herzig, Stephan; Hofmann, Susanna; Holleman, Cassie Lynn; Jastroch, Martin; Keipert, Susanne; Kleinert, Maximilian; Knerr, Patrick J; Kulaj, Konxhe; Legutko, Beata; Lickert, Heiko; Liu, Xue; Luippold, Gerd; Lutter, Dominik; Malogajski, Emilija; Medina, Marta Tarquis; Mowery, Stephanie A; Blutke, Andreas; Pe...     »
Abstract:
Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR) should be activated or inhibited for the treatment of obesity. Gipr was recently demonstrated in hypothalamic feeding centers, but the physiological relevance of CNS Gipr remains unknown. Here we show that HFD-fed CNS-Gipr KO mice and humanized (h)GIPR knockin mice with CNS-hGIPR deletion show decreased body weight and improved glucose metabolism. In DIO mice, acute central and peripheral administra...     »
Zeitschriftentitel:
Cell Metab
Jahr:
2021
Band / Volume:
33
Heft / Issue:
4
Seitenangaben Beitrag:
833-844.e5
Volltext / DOI:
doi:10.1016/j.cmet.2021.01.015
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33571454
Print-ISSN:
1550-4131
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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