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Titel:

Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Park, Joonhee; Daniels, Jay; Wartewig, Tim; Ringbloom, Kimberly G; Martinez-Escala, Maria Estela; Choi, Sara; Thomas, Jane J; Doukas, Peter G; Yang, Jingyi; Snowden, Caroline; Law, Calvin; Lee, Yujin; Lee, Katie; Zhang, Yancong; Conran, Carly; Tegtmeyer, Kyle; Mo, Samuel H; Pease, David R; Jothishankar, Balaji; Kwok, Pui-Yan; Abdulla, Farah R; Pro, Barbara; Louissaint, Abner; Boggon, Titus J; Sosman, Jeffrey; Guitart, Joan; Rao, Deepak; Ruland, Jürgen; Choi, Jaehyuk
Abstract:
Cutaneous T-cell lymphomas (CTCLs) are a clinically heterogeneous collection of lymphomas of the skin-homing T cell. To identify molecular drivers of disease phenotypes, we assembled representative samples of CTCLs from patients with diverse disease subtypes and stages. Via DNA/RNA-sequencing, immunophenotyping, and ex vivo functional assays, we identified the landscape of putative driver genes, elucidated genetic relationships between CTCLs across disease stages, and inferred molecular subtypes...     »
Zeitschriftentitel:
Blood
Jahr:
2021
Band / Volume:
138
Heft / Issue:
14
Seitenangaben Beitrag:
1225-1236
Volltext / DOI:
doi:10.1182/blood.2020009655
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34115827
Print-ISSN:
0006-4971
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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