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Titel:

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients.

Dokumenttyp:
Journal Article
Autor(en):
Matthaei, Johannes; Brockmöller, Jürgen; Steimer, Werner; Pischa, Konstanze; Leucht, Stefan; Kullmann, Maria; Jensen, Ole; Ouethy, Typhaine; Tzvetkov, Mladen Vassilev; Rafehi, Muhammad
Abstract:
The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics. Apart from interindividual differences in the activity of the metabolising enzymes cytochrome P450 (CYP) 2D6 and 2C19, genetic polymorphism of the hepatic influx transporter organic cation transporter 1 (OCT1) could be contributing to interindividual variation in pharmacokinetics. Here, the impact of OCT1 genetic variation on the phar...     »
Zeitschriftentitel:
Front Pharmacol
Jahr:
2021
Band / Volume:
12
Volltext / DOI:
doi:10.3389/fphar.2021.688950
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34093211
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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