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Titel:

Immunosuppressant quantification in intravenous microdialysate - towards novel quasi-continuous therapeutic drug monitoring in transplanted patients.

Dokumenttyp:
Journal Article
Autor(en):
Weber, Susanne; Tombelli, Sara; Giannetti, Ambra; Trono, Cosimo; O'Connell, Mark; Wen, Ming; Descalzo, Ana B; Bittersohl, Heike; Bietenbeck, Andreas; Marquet, Pierre; Renders, Lutz; Orellana, Guillermo; Baldini, Francesco; Luppa, Peter B
Abstract:
OBJECTIVES: Therapeutic drug monitoring (TDM) plays a crucial role in personalized medicine. It helps clinicians to tailor drug dosage for optimized therapy through understanding the underlying complex pharmacokinetics and pharmacodynamics. Conventional, non-continuous TDM fails to provide real-time information, which is particularly important for the initial phase of immunosuppressant therapy, e.g., with cyclosporine (CsA) and mycophenolic acid (MPA). METHODS: We analyzed the time course over 8...     »
Zeitschriftentitel:
Clin Chem Lab Med
Jahr:
2021
Band / Volume:
59
Heft / Issue:
5
Seitenangaben Beitrag:
935-945
Volltext / DOI:
doi:10.1515/cclm-2020-1542
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33554521
Print-ISSN:
1434-6621
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann); Institut für Klinische Chemie und Pathobiochemie
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