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Titel:

Lymphocyte Infiltration Determines the Hypoxia-Dependent Response to Definitive Chemoradiation in Head-and-Neck Cancer: Results from a Prospective Imaging Trial.

Dokumenttyp:
Journal Article
Autor(en):
Nicolay, Nils H; Rühle, Alexander; Wiedenmann, Nicole; Niedermann, Gabriele; Mix, Michael; Weber, Wolfgang A; Baltas, Dimos; Werner, Martin; Kayser, Gian; Grosu, Anca-L
Abstract:
Tumor hypoxia in head-and-neck squamous cell carcinoma (HNSCC) leads to an immunosuppressive microenvironment and reduces the response to radiotherapy. In this prospective imaging trial, we investigated potential interactions between functional hypoxia imaging and infiltrating lymphocyte levels as a potential predictor for treatment response in HNSCC patients. Methods: In total, 49 patients receiving definitive chemoradiation for locally advanced HNSCCs underwent pretherapeutic biopsies and peri...     »
Zeitschriftentitel:
J Nucl Med
Jahr:
2021
Band / Volume:
62
Heft / Issue:
4
Seitenangaben Beitrag:
471-478
Volltext / DOI:
doi:10.2967/jnumed.120.248633
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32859699
Print-ISSN:
0161-5505
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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