Benutzer: Gast  Login
Titel:

Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Friedrich, Mirco; Sankowski, Roman; Bunse, Lukas; Kilian, Michael; Green, Edward; Ramallo Guevara, Carina; Pusch, Stefan; Poschet, Gernot; Sanghvi, Khwab; Hahn, Markus; Bunse, Theresa; Münch, Philipp; Gegner, Hagen M; Sonner, Jana K; von Landenberg, Anna; Cichon, Frederik; Aslan, Katrin; Trobisch, Tim; Schirmer, Lucas; Abu-Sammour, Denis; Kessler, Tobias; Ratliff, Miriam; Schrimpf, Daniel; Sahm, Felix; Hopf, Carsten; Heiland, Dieter H; Schnell, Oliver; Beck, Jürgen; Böttcher, Chotima; Fernandez-...     »
Abstract:
The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single-cell profiling and demonstrate their strict control by the tumor genotype: in isocitrate dehydrogenase (IDH)-mutant tumors, differentiation of infiltrating myeloid cells is blocked, resulting in an immature phenotype. In late-stage gliomas, monocyte-derived macrophages drive tolerogenic alignment of the microenvironment...     »
Zeitschriftentitel:
Nat. Cancer
Jahr:
2021
Band / Volume:
2
Heft / Issue:
7
Seitenangaben Beitrag:
723-740
Volltext / DOI:
doi:10.1038/s43018-021-00201-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35121943
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
 BibTeX