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Title:

Genome-Wide Association Study Identifies Risk Loci for Cluster Headache.

Document type:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Author(s):
O'Connor, Emer; Fourier, Carmen; Ran, Caroline; Sivakumar, Prasanth; Liesecke, Franziska; Southgate, Laura; Harder, Aster V E; Vijfhuizen, Lisanne S; Yip, Janice; Giffin, Nicola; Silver, Nicholas; Ahmed, Fayyaz; Hostettler, Isabel C; Davies, Brendan; Cader, M Zameel; Simpson, Benjamin S; Sullivan, Roisin; Efthymiou, Stephanie; Adebimpe, Joycee; Quinn, Olivia; Campbell, Ciaran; Cavalleri, Gianpiero L; Vikelis, Michail; Kelderman, Tim; Paemeleire, Koen; Kilbride, Emer; Grangeon, Lou; Lagrata, Susi...     »
Abstract:
OBJECTIVE: This study was undertaken to identify susceptibility loci for cluster headache and obtain insights into relevant disease pathways. METHODS: We carried out a genome-wide association study, where 852 UK and 591 Swedish cluster headache cases were compared with 5,614 and 1,134 controls, respectively. Following quality control and imputation, single variant association testing was conducted using a logistic mixed model for each cohort. The 2 cohorts were subsequently combined in a merged...     »
Journal title abbreviation:
Ann Neurol
Year:
2021
Journal volume:
90
Journal issue:
2
Pages contribution:
193-202
Fulltext / DOI:
doi:10.1002/ana.26150
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34184781
Print-ISSN:
0364-5134
TUM Institution:
Neurochirurgische Klinik und Poliklinik
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