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Titel:

ANGPTL6 Genetic Variants Are an Underlying Cause of Familial Intracranial Aneurysms.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hostettler, Isabel C; O'Callaghan, Benjamin; Bugiardini, Enrico; O'Connor, Emer; Vandrovcova, Jana; Davagnanam, Indran; Alg, Varinder; Bonner, Stephen; Walsh, Daniel; Bulters, Diederik; Kitchen, Neil; Brown, Martin M; Grieve, Joan; Werring, David J; Houlden, Henry
Abstract:
PURPOSE: To understand the role of the angiopoietin-like 6 gene (ANGPTL6) in intracranial aneurysms (IAs), we investigated its role in a large cohort of familial IAs. METHODS: Individuals with family history of IA were recruited to the Genetic and Observational Subarachnoid Haemorrhage (GOSH) study. The ANGPTL6 gene was sequenced using Sanger sequencing. Identified genetic variants were compared to a control population. RESULTS: We found 6 rare ANGPTL6 genetic variants in 9/275 individuals with...     »
Zeitschriftentitel:
Neurology
Jahr:
2021
Band / Volume:
96
Heft / Issue:
6
Seitenangaben Beitrag:
e947-e955
Volltext / DOI:
doi:10.1212/WNL.0000000000011125
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33106390
Print-ISSN:
0028-3878
TUM Einrichtung:
Neurochirurgische Klinik und Poliklinik
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