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Titel:

Genome-Wide Association Study Identifies Risk Loci for Cluster Headache.

Dokumenttyp:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Autor(en):
O'Connor, Emer; Fourier, Carmen; Ran, Caroline; Sivakumar, Prasanth; Liesecke, Franziska; Southgate, Laura; Harder, Aster V E; Vijfhuizen, Lisanne S; Yip, Janice; Giffin, Nicola; Silver, Nicholas; Ahmed, Fayyaz; Hostettler, Isabel C; Davies, Brendan; Cader, M Zameel; Simpson, Benjamin S; Sullivan, Roisin; Efthymiou, Stephanie; Adebimpe, Joycee; Quinn, Olivia; Campbell, Ciaran; Cavalleri, Gianpiero L; Vikelis, Michail; Kelderman, Tim; Paemeleire, Koen; Kilbride, Emer; Grangeon, Lou; Lagrata, Susi...     »
Abstract:
OBJECTIVE: This study was undertaken to identify susceptibility loci for cluster headache and obtain insights into relevant disease pathways. METHODS: We carried out a genome-wide association study, where 852 UK and 591 Swedish cluster headache cases were compared with 5,614 and 1,134 controls, respectively. Following quality control and imputation, single variant association testing was conducted using a logistic mixed model for each cohort. The 2 cohorts were subsequently combined in a merged...     »
Zeitschriftentitel:
Ann Neurol
Jahr:
2021
Band / Volume:
90
Heft / Issue:
2
Seitenangaben Beitrag:
193-202
Volltext / DOI:
doi:10.1002/ana.26150
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34184781
Print-ISSN:
0364-5134
TUM Einrichtung:
Neurochirurgische Klinik und Poliklinik
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