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Titel:

Inhibition of Tumor-Host Cell Interactions Using Synthetic Heparin Mimetics.

Dokumenttyp:
Article; Journal Article
Autor(en):
Gockel, Lukas M; Heyes, Martin; Li, Honglian; Al Nahain, Abdullah; Gorzelanny, Christian; Schlesinger, Martin; Holdenrieder, Stefan; Li, Jin-Ping; Ferro, Vito; Bendas, Gerd
Abstract:
Low-molecular-weight heparin (LMWH) is the guideline-based drug for antithrombotic treatment of cancer patients, while its direct antitumor effects are a matter of ongoing debate. Although therapeutically established for decades, LMWH has several drawbacks mainly associated with its origin from animal sources. Aiming to overcome these limitations, a library of synthetic heparin mimetic polymers consisting of homo- and copolymers of sulfonated and carboxylated noncarbohydrate monomers has recentl...     »
Zeitschriftentitel:
ACS Appl Mater Interfaces
Jahr:
2021
Band / Volume:
13
Heft / Issue:
6
Seitenangaben Beitrag:
7080-7093
Volltext / DOI:
doi:10.1021/acsami.0c20744
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33533245
Print-ISSN:
1944-8244
TUM Einrichtung:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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