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Titel:

Developing a Nationwide Infrastructure for Therapeutic Drug Monitoring of Targeted Oral Anticancer Drugs: The ON-TARGET Study Protocol.

Dokumenttyp:
Article; Journal Article
Autor(en):
Mc Laughlin, Anna M; Schmulenson, Eduard; Teplytska, Olga; Zimmermann, Sebastian; Opitz, Patrick; Groenland, Stefanie L; Huitema, Alwin D R; Steeghs, Neeltje; Müller, Lothar; Fuxius, Stefan; Illerhaus, Gerald; Joerger, Markus; Mayer, Frank; Fuhr, Uwe; Holdenrieder, Stefan; Hempel, Georg; Scherf-Clavel, Oliver; Jaehde, Ulrich; Kloft, Charlotte; For The On-Target Study Consortium
Abstract:
Exposure-efficacy and/or exposure-toxicity relationships have been identified for up to 80% of oral anticancer drugs (OADs). Usually, OADs are administered at fixed doses despite their high interindividual pharmacokinetic variability resulting in large differences in drug exposure. Consequently, a substantial proportion of patients receive a suboptimal dose. Therapeutic Drug Monitoring (TDM), i.e., dosing based on measured drug concentrations, may be used to improve treatment outcomes. The prosp...     »
Zeitschriftentitel:
Cancers (Basel)
Jahr:
2021
Band / Volume:
13
Heft / Issue:
24
Volltext / DOI:
doi:10.3390/cancers13246281
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34944899
TUM Einrichtung:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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