Benutzer: Gast  Login
Titel:

Are Proinflammatory Cytokines Relevant for the Diagnosis of Prostate Cancer?

Dokumenttyp:
Article; Journal Article; Observational Study
Autor(en):
Garrido, Manuel M; Ribeiro, Ruy M; Krüger, Kimberly; Pinheiro, Luís C; Guimarães, João T; Holdenrieder, Stefan
Abstract:
BACKGROUND/AIM: Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml. PATIENTS AND METHODS: Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1β, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regarding presence of PCa and disease severity. RESULTS: Significant differences between PCa patients and controls were found for IL-6 (p=0.002), IL-8 (p=0.030), and TNF-α (p=0.009), although they were not predictors of PCa in a logistic regression analysis. In addition, IL-6 and TNF-α levels were significantly higher in patients with high-risk PCa (p<0.05). No significant differences were observed regarding the other cytokines. CONCLUSION: In patients with PSA levels between 2-10 ng/ml, IL-6, IL-8, and TNF-α are associated with PCa, and IL-6 and TNF-α are associated with high-risk PCa.
Zeitschriftentitel:
Anticancer Res
Jahr:
2021
Band / Volume:
41
Heft / Issue:
6
Seitenangaben Beitrag:
3067-3073
Volltext / DOI:
doi:10.21873/anticanres.15090
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34083299
Print-ISSN:
0250-7005
TUM Einrichtung:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
 BibTeX