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Titel:

Putative Origins of Cell-Free DNA in Humans: A Review of Active and Passive Nucleic Acid Release Mechanisms.

Dokumenttyp:
Review; Journal Article; Review
Autor(en):
Grabuschnig, Stefan; Bronkhorst, Abel Jacobus; Holdenrieder, Stefan; Rosales Rodriguez, Ingund; Schliep, Klaus Peter; Schwendenwein, Daniel; Ungerer, Vida; Sensen, Christoph Wilhelm
Abstract:
Through various pathways of cell death, degradation, and regulated extrusion, partial or complete genomes of various origins (e.g., host cells, fetal cells, and infiltrating viruses and microbes) are continuously shed into human body fluids in the form of segmented cell-free DNA (cfDNA) molecules. While the genetic complexity of total cfDNA is vast, the development of progressively efficient extraction, high-throughput sequencing, characterization via bioinformatics procedures, and detection hav...     »
Zeitschriftentitel:
Int J Mol Sci
Jahr:
2020
Band / Volume:
21
Heft / Issue:
21
Volltext / DOI:
doi:10.3390/ijms21218062
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33137955
Print-ISSN:
1422-0067
TUM Einrichtung:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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