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Titel:

Mitochondrial Regulation of the 26S Proteasome.

Dokumenttyp:
Journal Article
Autor(en):
Meul, Thomas; Berschneider, Korbinian; Schmitt, Sabine; Mayr, Christoph H; Mattner, Laura F; Schiller, Herbert B; Yazgili, Ayse S; Wang, Xinyuan; Lukas, Christina; Schlesser, Camille; Prehn, Cornelia; Adamski, Jerzy; Graf, Elisabeth; Schwarzmayr, Thomas; Perocchi, Fabiana; Kukat, Alexandra; Trifunovic, Aleksandra; Kremer, Laura; Prokisch, Holger; Popper, Bastian; von Toerne, Christine; Hauck, Stefanie M; Zischka, Hans; Meiners, Silke
Abstract:
The proteasome is the main proteolytic system for targeted protein degradation in the cell and is fine-tuned according to cellular needs. Here, we demonstrate that mitochondrial dysfunction and concomitant metabolic reprogramming of the tricarboxylic acid (TCA) cycle reduce the assembly and activity of the 26S proteasome. Both mitochondrial mutations in respiratory complex I and treatment with the anti-diabetic drug metformin impair 26S proteasome activity. Defective 26S assembly is reversible a...     »
Zeitschriftentitel:
Cell Rep
Jahr:
2020
Band / Volume:
32
Heft / Issue:
8
Volltext / DOI:
doi:10.1016/j.celrep.2020.108059
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32846138
Print-ISSN:
2211-1247
TUM Einrichtung:
Institut für Humangenetik; Institut für Toxikologie und Umwelthygiene
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