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Title:

Copper - a novel stimulator of autophagy.

Document type:
Journal Article; Comment
Author(s):
Zischka, Hans; Kroemer, Guido
Abstract:
Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper Tsang et al. (Nat Cell Biol, doi: 10.1038/s41556-020-0481-4) demonstrate that copper binds with high affinity to a designated interaction site in the pro-autophagic kinases ULK1 and ULK2. Chelation of copper or genetic deletion of this copper-binding site inhibits autophagy and hence reduces the fitness of KRAS-induced cancers. These findings suggest t...     »
Journal title abbreviation:
Cell Stress
Year:
2020
Journal volume:
4
Journal issue:
5
Pages contribution:
92-94
Fulltext / DOI:
doi:10.15698/cst2020.05.218
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32420529
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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