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Title:

Chemical activation of SAT1 corrects diet-induced metabolic syndrome.

Document type:
Journal Article
Author(s):
Castoldi, Francesca; Hyvönen, Mervi T; Durand, Sylvère; Aprahamian, Fanny; Sauvat, Allan; Malik, Shoaib A; Baracco, Elisa Elena; Vacchelli, Erika; Opolon, Paule; Signolle, Nicolas; Lefevre, Déborah; Bossut, Noelie; Eisenberg, Tobias; Dammbrueck, Christopher; Pendl, Tobias; Kremer, Margerie; Lachkar, Sylvie; Einer, Claudia; Michalke, Bernhard; Zischka, Hans; Madeo, Frank; Keinänen, Tuomo A; Maiuri, Maria Chiara; Pietrocola, Federico; Kroemer, Guido
Abstract:
The pharmacological targeting of polyamine metabolism is currently under the spotlight for its potential in the prevention and treatment of several age-associated disorders. Here, we report the finding that triethylenetetramine dihydrochloride (TETA), a copper-chelator agent that can be safely administered to patients for the long-term treatment of Wilson disease, exerts therapeutic benefits in animals challenged with hypercaloric dietary regimens. TETA reduced obesity induced by high-fat diet,...     »
Journal title abbreviation:
Cell Death Differ
Year:
2020
Journal volume:
27
Journal issue:
10
Pages contribution:
2904-2920
Fulltext / DOI:
doi:10.1038/s41418-020-0550-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32376874
Print-ISSN:
1350-9047
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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