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Title:

Modeling RBE-weighted dose variations in irregularly moving abdominal targets treated with carbon ion beams.

Document type:
Journal Article
Author(s):
Meschini, Giorgia; Kamp, Florian; Hofmaier, Jan; Reiner, Michael; Sharp, Gregory; Paganetti, Harald; Belka, Claus; Wilkens, Jan J; Carlson, David J; Parodi, Katia; Baroni, Guido; Riboldi, Marco
Abstract:
PURPOSE: To model four-dimensional (4D) relative biological effectiveness (RBE)-weighted dose variations in abdominal lesions treated with scanned carbon ion beam in case of irregular breathing motion. METHODS: The proposed method, referred to as bioWED method, combines the simulation of tumor motion in a patient- and beam-specific water equivalent depth (WED)-space with RBE modeling, aiming at the estimation of RBE-weighted dose changes due to respiratory motion. The method was validated on a p...     »
Journal title abbreviation:
Med Phys
Year:
2020
Journal volume:
47
Journal issue:
7
Pages contribution:
2768-2778
Fulltext / DOI:
doi:10.1002/mp.14135
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32162332
Print-ISSN:
0094-2405
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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