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Titel:

Revisiting the Warburg effect: historical dogma versus current understanding.

Dokumenttyp:
Journal Article
Autor(en):
Vaupel, Peter; Multhoff, Gabriele
Abstract:
Contrary to Warburg's original thesis, accelerated aerobic glycolysis is not a primary, permanent and universal consequence of dysfunctional or impaired mitochondria compensating for poor ATP yield per mole of glucose. Instead, in most tumours the Warburg effect is an essential part of a 'selfish' metabolic reprogramming, which results from the interplay between (normoxic/hypoxic) hypoxia-inducible factor-1 (HIF-1) overexpression, oncogene activation (cMyc, Ras), loss of function of tumour suppr...     »
Zeitschriftentitel:
J Physiol
Jahr:
2021
Band / Volume:
599
Heft / Issue:
6
Seitenangaben Beitrag:
1745-1757
Volltext / DOI:
doi:10.1113/JP278810
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33347611
Print-ISSN:
0022-3751
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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