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Titel:

Regional Hyperthermia Enhances Mesenchymal Stem Cell Recruitment to Tumor Stroma: Implications for Mesenchymal Stem Cell-Based Tumor Therapy.

Dokumenttyp:
Journal Article
Autor(en):
Tutter, Mariella; Schug, Christina; Schmohl, Kathrin A; Urnauer, Sarah; Kitzberger, Carolin; Schwenk, Nathalie; Petrini, Matteo; Zach, Christian; Ziegler, Sibylle; Bartenstein, Peter; Weber, Wolfgang A; Multhoff, Gabriele; Wagner, Ernst; Lindner, Lars H; Nelson, Peter J; Spitzweg, Christine
Abstract:
The tropism of mesenchymal stem cells (MSCs) for tumors forms the basis for their use as delivery vehicles for the tumor-specific transport of therapeutic genes, such as the theranostic sodium iodide symporter (NIS). Hyperthermia is used as an adjuvant for various tumor therapies and has been proposed to enhance leukocyte recruitment. Here, we describe the enhanced recruitment of adoptively applied NIS-expressing MSCs to tumors in response to regional hyperthermia. Hyperthermia (41°C, 1 h) of hu...     »
Zeitschriftentitel:
Mol Ther
Jahr:
2021
Band / Volume:
29
Heft / Issue:
2
Seitenangaben Beitrag:
788-803
Volltext / DOI:
doi:10.1016/j.ymthe.2020.10.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33068779
Print-ISSN:
1525-0016
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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