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Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Leonard, Cathy; Montamat, Guillem; Davril, Caroline; Domingues, Olivia; Hunewald, Oliver; Revets, Dominique; Guerin, Coralie; Blank, Simon; Heckendorn, Justine; Jardon, Gauthier; Hentges, François; Ollert, Markus
Titel:
Comprehensive mapping of immune tolerance yields a regulatory TNF receptor 2 signature in a murine model of successful Fel d 1-specific immunotherapy using high-dose CpG adjuvant.
Abstract:
BACKGROUND: The prevalence of allergy to cat is expanding worldwide. Allergen-specific immunotherapy (AIT) has advantages over symptomatic pharmacotherapy and promises long-lasting disease control in allergic patients. However, there is still a need to improve cat AIT regarding efficacy, safety, and adherence to the treatment. Here, we aim to boost immune tolerance to the major cat allergen Fel d 1 by increasing the anti-inflammatory activity of AIT with the established immunomodulatory adjuvant...     »
Zeitschriftentitel:
Allergy
Jahr:
2021
Band / Volume:
76
Heft / Issue:
7
Seitenangaben Beitrag:
2153-2165
Volltext / DOI:
doi:10.1111/all.14716
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33345329
Print-ISSN:
0105-4538
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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