Allergic Reactions to COVID-19-Vaccinations - What ENT-Doctors should know Part 1: General Aspects of Allergies to Vaccines, immunological Basis of Allergies to Vaccines, Immune Mechanisms of allergic and pseudo-allergic Reactions Part 2: Characteristics of the mRNA-Vaccines BNT162b2 and mRNA-1273 for the Prophylaxis of COVID-19, other Vaccine-Candidates and associated Immune Phenomena Part 3: Practical aspects of the Prophylaxis, Diagnosis and Treatment of Allergies due to COVID-19-Vaccines     «

Allergic Reactions to COVID-19-Vaccinations - What ENT-Doctors should know Part 1: General Aspects of Allergies to Vaccines, immunological Basis of Allergies to Vaccines, Immune Mechanisms of allergic and pseudo-allergic Reactions Part 2: Characteristics of the mRNA-Vaccines BNT162b2 and mRNA-1273 for the Prophylaxis of COVID-19, other Vaccine-Candidates and associated Immune Phenomena Part 3: Practical aspects of the Prophylaxis, Diagnosis and Treatment of Allergies due to COVID-1...     »

Vaccinations are the gold-standard in order to prevent dangerous infectious diseases. Within 12 months since the RNA sequence of SARS-COV2 has been published already two RNA vaccines against COVID-19 have been licensed and are broadly used in many relevant parts of the world. Matching the challenge of an unprecedented global pandemic unique collaborative approaches have made available several vaccines based on a variety of technological platforms that are under current development. This article explains the characteristics, biology and pharmacology of subunit-vaccines, inactivated and attenuated vaccines, Virus-like-Particle vaccines, recombinant strategies based on adenoviral vectors and newly developed and first time in human licensed RNA-vaccines that came into scope recently. Allergic reactions against the vaccine and its components have been reported but are yet uncommon, however need good documentation such as other side-effects and immune-phenomena. In rare cases where allergy against vaccine components such as PEGs is considered, such PEGs can be tested using a skin-prick test. Development of innovative vaccine technology and antiviral medication is of strategic relevance in the best sense of "pandemic preparedness" for the future.     «

Vaccinations are the gold-standard in order to prevent dangerous infectious diseases. Within 12 months since the RNA sequence of SARS-COV2 has been published already two RNA vaccines against COVID-19 have been licensed and are broadly used in many relevant parts of the world. Matching the challenge of an unprecedented global pandemic unique collaborative approaches have made available several vaccines based on a variety of technological platforms that are under current development. This article...     »