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Title:

MEK1/2 regulates APOBEC3B and polymerase iota-induced mutagenesis in head and neck cancer cells.

Document type:
Journal Article
Author(s):
Schulz, Dominik; Piontek, Guido; Zissler, Ulrich M; Multhoff, Gabriele; Wirth, Markus; Pickhard, Anja
Abstract:
Resistance to chemotherapy provides a major challenge in treatment of metastatic cancer. Prolonged exposure to almost any drug regimen leads to the formation of resistant subclones in almost all advanced solid tumors. Tumor heterogeneity because of intrinsic genetic instability is seen as one of the major contributing factors. In this work, we present evidence that genetic instability measured by mutation frequency is induced by treatment with the EGFR inhibitor afatinib or cisplatin in head and...     »
Journal title abbreviation:
Am J Cancer Res
Year:
2021
Journal volume:
11
Journal issue:
11
Pages contribution:
5581-5590
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34873481
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Molekulare Allergologie (Prof. Schmidt-Weber)
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