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Titel:

Drug Repurposing of Pantoprazole and Vitamin C Targeting Tumor Microenvironment Conditions Improves Anticancer Effect in Metastatic Castration-Resistant Prostate Cancer.

Dokumenttyp:
Journal Article
Autor(en):
Li, Zhoulei; He, Peng; Long, Yali; Yuan, Gang; Shen, Wanqing; Chen, Zhifeng; Zhang, Bing; Wang, Yue; Yue, Dianchao; Seidl, Christof; Zhang, Xiangsong
Abstract:
The effective and economical therapeutic strategy for metastatic castration-resistant prostate cancer (mCRPC) is still requested from patients, who are not available for Lu-177 or Ra-223 treatment. Drug repurposing as a cost-effective and time-saving alternative to traditional drug development has been increasingly discussed. Proton pump inhibitors (PPIs) such as pantroprazole, which are commonly used as antacids, have also been shown to be effective in cancer chemoprevention via induction of ap...     »
Zeitschriftentitel:
Front Oncol
Jahr:
2021
Band / Volume:
11
Volltext / DOI:
doi:10.3389/fonc.2021.660320
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34307134
Print-ISSN:
2234-943X
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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