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Title:

Drug Repurposing of Pantoprazole and Vitamin C Targeting Tumor Microenvironment Conditions Improves Anticancer Effect in Metastatic Castration-Resistant Prostate Cancer.

Document type:
Journal Article
Author(s):
Li, Zhoulei; He, Peng; Long, Yali; Yuan, Gang; Shen, Wanqing; Chen, Zhifeng; Zhang, Bing; Wang, Yue; Yue, Dianchao; Seidl, Christof; Zhang, Xiangsong
Abstract:
The effective and economical therapeutic strategy for metastatic castration-resistant prostate cancer (mCRPC) is still requested from patients, who are not available for Lu-177 or Ra-223 treatment. Drug repurposing as a cost-effective and time-saving alternative to traditional drug development has been increasingly discussed. Proton pump inhibitors (PPIs) such as pantroprazole, which are commonly used as antacids, have also been shown to be effective in cancer chemoprevention via induction of ap...     »
Journal title abbreviation:
Front Oncol
Year:
2021
Journal volume:
11
Fulltext / DOI:
doi:10.3389/fonc.2021.660320
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34307134
Print-ISSN:
2234-943X
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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