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Title:

Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease.

Document type:
Article; Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Joseph-Mathurin, Nelly; Wang, Guoqiao; Kantarci, Kejal; Jack, Clifford R; McDade, Eric; Hassenstab, Jason; Blazey, Tyler M; Gordon, Brian A; Su, Yi; Chen, Gengsheng; Massoumzadeh, Parinaz; Hornbeck, Russ C; Allegri, Ricardo F; Ances, Beau M; Berman, Sarah B; Brickman, Adam M; Brooks, William S; Cash, David M; Chhatwal, Jasmeer P; Chui, Helena C; Correia, Stephen; Cruchaga, Carlos; Farlow, Martin R; Fox, Nick C; Fulham, Michael; Ghetti, Bernardino; Graff-Radford, Neill R; Johnson, Keith A; Karch,...     »
Abstract:
OBJECTIVE: To investigate the inherent clinical risks associated with the presence of cerebral microhemorrhages (CMHs) or cerebral microbleeds and characterize individuals at high risk for developing hemorrhagic amyloid-related imaging abnormality (ARIA-H), we longitudinally evaluated families with dominantly inherited Alzheimer disease (DIAD). METHODS: Mutation carriers (n = 310) and noncarriers (n = 201) underwent neuroimaging, including gradient echo MRI sequences to detect CMHs, and neuropsy...     »
Journal title abbreviation:
Neurology
Year:
2021
Journal volume:
96
Journal issue:
12
Pages contribution:
e1632-e1645
Fulltext / DOI:
doi:10.1212/WNL.0000000000011542
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33495373
Print-ISSN:
0028-3878
TUM Institution:
617; Klinik und Poliklinik für Nuklearmedizin
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