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Titel:

Selective sodium iodide symporter (NIS) genetherapy of glioblastoma mediatedby EGFR-targeted lipopolyplexes.

Dokumenttyp:
Journal Article
Autor(en):
Spellerberg, Rebekka; Benli-Hoppe, Teoman; Kitzberger, Carolin; Berger, Simone; Schmohl, Kathrin A; Schwenk, Nathalie; Yen, Hsi-Yu; Zach, Christian; Schilling, Franz; Weber, Wolfgang A; Kälin, Roland E; Glass, Rainer; Nelson, Peter J; Wagner, Ernst; Spitzweg, Christine
Abstract:
Lipo-oligomers, post-functionalized with ligands to enhance targeting, represent promising new vehicles for the tumor-specific delivery of therapeutic genes such as the sodium iodide symporter (NIS). Due to its iodide trapping activity, NIS is a powerful theranostic tool for diagnostic imaging and the application of therapeutic radionuclides. 124I PET imaging allows non-invasive monitoring of the in vivo biodistribution of functional NIS expression, and application of 131I enables cytoreduction....     »
Zeitschriftentitel:
Mol Ther Oncolytics
Jahr:
2021
Band / Volume:
23
Seitenangaben Beitrag:
432-446
Volltext / DOI:
doi:10.1016/j.omto.2021.10.011
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34853814
TUM Einrichtung:
602; Klinik und Poliklinik für Nuklearmedizin
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