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Titel:

Important pharmacokinetic parameters for individualization of 177 Lu-PSMA therapy: A global sensitivity analysis for a physiologically-based pharmacokinetic model.

Dokumenttyp:
Article; Journal Article
Autor(en):
Hardiansyah, Deni; Kletting, Peter; Begum, Nusrat J; Eiber, Matthias; Beer, Ambros J; Pawiro, Supriyanto A; Glatting, Gerhard
Abstract:
PURPOSE: The knowledge of the contribution of anatomical and physiological parameters to interindividual pharmacokinetic differences could potentially be used to improve individualized treatment planning for radionuclide therapy. The aim of this study was therefore to identify the physiologically based pharmacokinetic (PBPK) model parameters that determine the interindividual variability of absorbed doses (ADs) to kidneys and tumor lesions in therapy with 177 Lu-labeled PSMA-targeting radioligan...     »
Zeitschriftentitel:
Med Phys
Jahr:
2021
Band / Volume:
48
Heft / Issue:
2
Seitenangaben Beitrag:
556-568
Volltext / DOI:
doi:10.1002/mp.14622
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33244792
Print-ISSN:
0094-2405
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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