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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Xu, Peng; Scott, Daniel C; Xu, Beisi; Yao, Yu; Feng, Ruopeng; Cheng, Li; Mayberry, Kalin; Wang, Yong-Dong; Bi, Wenjian; Palmer, Lance E; King, Moeko T; Wang, Hong; Li, Yuxin; Fan, Yiping; Alpi, Arno F; Li, Chunliang; Peng, Junmin; Papizan, James; Pruett-Miller, Shondra M; Spallek, Ria; Bassermann, Florian; Cheng, Yong; Schulman, Brenda A; Weiss, Mitchell J
Title:
FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis.
Abstract:
The histone mark H3K27me3 and its reader/writer polycomb repressive complex 2 (PRC2) mediate widespread transcriptional repression in stem and progenitor cells. Mechanisms that regulate this activity are critical for hematopoietic development but are poorly understood. Here we show that the E3 ubiquitin ligase F-box only protein 11 (FBXO11) relieves PRC2-mediated repression during erythroid maturation by targeting its newly identified substrate bromo adjacent homology domain-containing 1 (BAHD1)...     »
Journal title abbreviation:
Blood
Year:
2021
Journal volume:
137
Journal issue:
2
Pages contribution:
155-167
Fulltext / DOI:
doi:10.1182/blood.2020007809
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33156908
Print-ISSN:
0006-4971
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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