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Title:

Multimodal Precision Imaging of Pulmonary Nanoparticle Delivery in Mice: Dynamics of Application, Spatial Distribution, and Dosimetry.

Document type:
Journal Article
Author(s):
Yang, Lin; Gradl, Regine; Dierolf, Martin; Möller, Winfried; Kutschke, David; Feuchtinger, Annette; Hehn, Lorenz; Donnelley, Martin; Günther, Benedikt; Achterhold, Klaus; Walch, Axel; Stoeger, Tobias; Razansky, Daniel; Pfeiffer, Franz; Morgan, Kaye S; Schmid, Otmar
Abstract:
Targeted delivery of nanomedicine/nanoparticles (NM/NPs) to the site of disease (e.g., the tumor or lung injury) is of vital importance for improved therapeutic efficacy. Multimodal imaging platforms provide powerful tools for monitoring delivery and tissue distribution of drugs and NM/NPs. This study introduces a preclinical imaging platform combining X-ray (two modes) and fluorescence imaging (three modes) techniques for time-resolved in vivo and spatially resolved ex vivo visualization of mou...     »
Journal title abbreviation:
Small
Year:
2019
Journal volume:
15
Journal issue:
49
Fulltext / DOI:
doi:10.1002/smll.201904112
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31639283
Print-ISSN:
1613-6810
TUM Institution:
Institut für Diagnostische und Interventionelle Radiologie
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