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Titel:

Association of paraspinal muscle water-fat MRI-based measurements with isometric strength measurements.

Dokumenttyp:
Journal Article
Autor(en):
Schlaeger, Sarah; Inhuber, Stephanie; Rohrmeier, Alexander; Dieckmeyer, Michael; Freitag, Friedemann; Klupp, Elisabeth; Weidlich, Dominik; Feuerriegel, Georg; Kreuzpointner, Florian; Schwirtz, Ansgar; Rummeny, Ernst J; Zimmer, Claus; Kirschke, Jan S; Karampinos, Dimitrios C; Baum, Thomas
Abstract:
Chemical shift encoding-based water-fat MRI derived proton density fat fraction (PDFF) of the paraspinal muscles has been emerging as a surrogate marker in subjects with sarcopenia, lower back pain, injuries and neuromuscular disorders. The present study investigates the performance of paraspinal muscle PDFF and cross-sectional area (CSA) in predicting isometric muscle strength.Twenty-six healthy subjects (57.7% women; age: 30 ± 6 years) underwent 3T axial MRI of the lumbar spine using a six-echo 3D spoiled gradient echo sequence for chemical shift encoding-based water-fat separation. Erector spinae and psoas muscles were segmented bilaterally from L2 level to L5 level to determine CSA and PDFF. Muscle flexion and extension maximum isometric torque values [Nm] at the back were measured with an isokinetic dynamometer.Significant correlations between CSA and muscle strength measurements were observed for erector spinae muscle CSA (r = 0.40; p = 0.044) and psoas muscle CSA (r = 0.61; p = 0.001) with relative flexion strength. Erector spinae muscle PDFF correlated significantly with relative muscle strength (extension: r = -0.51; p = 0.008; flexion: r = -0.54; p = 0.005). Erector spinae muscle PDFF, but not CSA, remained a statistically significant (p < 0.05) predictor of relative extensor strength in multivariate regression models (R = 0.34; p = 0.002).PDFF measurements improved the prediction of paraspinal muscle strength beyond CSA. Therefore, chemical shift encoding-based water-fat MRI may be used to detect subtle changes in the paraspinal muscle composition.o We investigated the association of paraspinal muscle fat fraction based on chemical shift encoding-based water-fat MRI with isometric strength measurements in healthy subjects. o Erector spinae muscle PDFF correlated significantly with relative muscle strength. o PDFF measurements improved prediction of paraspinal muscle strength beyond CSA.
Zeitschriftentitel:
Eur Radiol
Jahr:
2019
Band / Volume:
29
Heft / Issue:
2
Seitenangaben Beitrag:
599-608
Volltext / DOI:
doi:10.1007/s00330-018-5631-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30014202
Print-ISSN:
0938-7994
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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