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Titel:

Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients.

Dokumenttyp:
Journal Article
Autor(en):
Reber, Josefine; Willershäuser, Monja; Karlas, Angelos; Paul-Yuan, Korbinian; Diot, Gael; Franz, Daniela; Fromme, Tobias; Ovsepian, Saak V; Beziere, Nicolas; Dubikovskaya, Elena; Karampinos, Dimitrios C; Holzapfel, Christina; Hauner, Hans; Klingenspor, Martin; Ntziachristos, Vasilis
Abstract:
Metabolism is a fundamental process of life. However, non-invasive measurement of local tissue metabolism is limited today by a deficiency in adequate tools for in vivo observations. We designed a multi-modular platform that explored the relation between local tissue oxygen consumption, determined by label-free optoacoustic measurements of hemoglobin, and concurrent indirect calorimetry obtained during metabolic activation of brown adipose tissue (BAT). By studying mice and humans, we show how v...     »
Zeitschriftentitel:
Cell Metab
Jahr:
2018
Band / Volume:
27
Heft / Issue:
3
Seitenangaben Beitrag:
689-701.e4
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cmet.2018.02.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29514074
Print-ISSN:
1550-4131
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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