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Title:

PD-L1 and PD-1 and characterization of tumor-infiltrating lymphocytes in high grade sarcomas of soft tissue - prognostic implications and rationale for immunotherapy.

Document type:
Journal Article
Author(s):
Boxberg, Melanie; Steiger, Katja; Lenze, Ulrich; Rechl, Hans; von Eisenhart-Rothe, Rüdiger; Wörtler, Klaus; Weichert, Wilko; Langer, Rupert; Specht, Katja
Abstract:
Therapies targeting programmed death 1-(PD-1) or its ligand (PD-L1), promoting antitumor T-cell activity have been successfully introduced into clinical practice. Clinical response correlates with PD-L1 expression by tumor cells or immune cells within the tumor microenvironment. The PD-L1/PD-1 axis and tumor microenvironment has been rarely studied in high-grade sarcomas of soft tissue (hSTS), a group of rare, genetically heterogenous and clinically aggressive tumors. We examined PD-L1 protein a...     »
Journal title abbreviation:
Oncoimmunology
Year:
2018
Journal volume:
7
Journal issue:
3
Pages contribution:
e1389366
Language:
eng
Fulltext / DOI:
doi:10.1080/2162402X.2017.1389366
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29399389
Print-ISSN:
2162-4011
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Orthopädie und Sportorthopädie
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