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Titel:

Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1α Modulation.

Dokumenttyp:
Journal Article
Autor(en):
Pagani, Andrea; Kirsch, B Manuela; Hopfner, Ursula; Aitzetmueller, Matthias M; Brett, Elizabeth A; Thor, Dominik; Mela, Petra; Machens, Hans-Guenther; Duscher, Dominik
Abstract:
BACKGROUND: Hypoxia-inducible factor 1α (HIF-1α), a transcription factor responsible for tissue homeostasis and regeneration, presents reduced functionality in advanced age. In addition to absence of oxygen, sequestration of iron also stimulates HIF-1α. Therefore, we analyzed the efficacy of the iron-chelator deferiprone (DFP) at stimulating dermal fibroblasts. OBJECTIVES: The main objective of this study was to quantify the DFP concentrations capable of stimulating dermal fibroblasts in vitro a...     »
Zeitschriftentitel:
Aesthet Surg J
Jahr:
2021
Band / Volume:
41
Heft / Issue:
4
Seitenangaben Beitrag:
514-524
Volltext / DOI:
doi:10.1093/asj/sjaa142
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32479616
Print-ISSN:
1090-820X
TUM Einrichtung:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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