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Titel:

SESN2 protects against denervated muscle atrophy through unfolded protein response and mitophagy.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Yang, Xiaofan; Xue, Pingping; Yuan, Meng; Xu, Xiang; Wang, Cheng; Li, Wenqing; Machens, Hans-Günther; Chen, Zhenbing
Abstract:
Denervation of skeletal muscles results in a rapid and programmed loss of muscle size and performance, termed muscle atrophy, which leads to a poor prognosis of clinical nerve repair. Previous researches considered this process a result of multiple factors, such as protein homeostasis disorder, mitochondrial dysfunction, endoplasmic reticulum stress (ERS), and apoptosis, while their intrinsic association remains to be explored. In this study, Sestrin2 (SESN2), a stress-inducible protein, was sho...     »
Zeitschriftentitel:
Cell Death Dis
Jahr:
2021
Band / Volume:
12
Heft / Issue:
9
Volltext / DOI:
doi:10.1038/s41419-021-04094-9
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34429398
TUM Einrichtung:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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