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Title:

Hyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenotyping of rat HCC.

Document type:
Journal Article
Author(s):
Bliemsrieder, Elisabeth; Kaissis, Georgios; Grashei, Martin; Topping, Geoffrey; Altomonte, Jennifer; Hundshammer, Christian; Lohöfer, Fabian; Heid, Irina; Keim, Dominik; Gebrekidan, Selamawit; Trajkovic-Arsic, Marija; Winkelkotte, Aline; Steiger, Katja; Nawroth, Roman; Siveke, Jens; Schwaiger, Markus; Makowski, Marcus; Schilling, Franz; Braren, Rickmer
Abstract:
The in vivo assessment of tissue metabolism represents a novel strategy for the evaluation of oncologic disease. Hepatocellular carcinoma (HCC) is a high-prevalence, high-mortality tumor entity often discovered at a late stage. Recent evidence indicates that survival differences depend on metabolic alterations in tumor tissue, with particular focus on glucose metabolism and lactate production. Here, we present an in vivo imaging technique for metabolic tumor phenotyping in rat models of HCC. End...     »
Journal title abbreviation:
Sci Rep
Year:
2021
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-020-80952-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33441943
Print-ISSN:
2045-2322
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Diagnostische und Interventionelle Radiologie; Klinik und Poliklinik für Nuklearmedizin; Urologische Klinik und Poliklinik
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