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- Dokumenttyp:
- Journal Article
- Autor(en):
- Einhellig, Heike C; Siebert, Eberhard; Bauknecht, Hans-C; Tietze, Anna; Graef, Josefine; Furth, Christian; Schulze, Daniel; Miszczuk, Milena; Bohner, Georg; Schatka, Imke; Makowski, Marcus R
- Titel:
- Comparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas.
- Abstract:
- To evaluate the diagnostic performance of magnetic resonance imaging (MRI) alone in comparison to positron emission tomography/ magnetic resonance imaging (PET/MRI) in patients with meningiomas. 57 patients with a total of 112 meningiomas of the brain were included. PET/MRI, including a fully diagnostic contrast enhanced MRI and PET, were acquired. PET/MRI was used as reference standard. The size and location of meningiomas was recorded. Likelihood-ratio chi-square tests were used to calculate p-values within logistic regression in order to compare different models. A multi-level logistic regression was applied to comply the hierarchical data structure. Multi-level regression adjusts for clustering in data was performed. The majority (n = 103) of meningiomas could be identified based on standard MRI sequences compared to PET/MRI. MRI alone achieved a sensitivity of 95% (95% CI 0.78, 0.99) and specificity of 88% (95% CI 0.58, 0.98). Based on intensity of contrast medium uptake, 97 meningiomas could be diagnosed with intense uptake (93.75%). Sensitivity was lowest with 74% for meningiomas < 0.5 cm3, high with 95% for meningiomas > 2cm3 and highest with 100% for meningiomas 0.5-1.0 cm3. Petroclival meningiomas showed lowest sensitivity with 88% compared to sphenoidal meningiomas with 94% and orbital meningiomas with 100%. Specificity of meningioma diagnostic with MRI was high with 100% for sphenoidal and hemispherical-dural meningiomas and meningiomas with 0.5-1.0 and 1.0-2.0 cm3. Overall MRI enables reliable detection of meningiomas compared to PET/MRI. PET/MRI imaging offers highest sensitivity and specificity for small or difficult located meningiomas.
- Zeitschriftentitel:
- Sci Rep
- Jahr:
- 2021
- Band / Volume:
- 11
- Heft / Issue:
- 1
- Volltext / DOI:
- doi:10.1038/s41598-021-87866-9
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/33907204
- Print-ISSN:
- 2045-2322
- TUM Einrichtung:
- Institut für Diagnostische und Interventionelle Radiologie
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