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Title:

Targeted Natural Killer Cell-Based Adoptive Immunotherapy for the Treatment of Patients with NSCLC after Radiochemotherapy: A Randomized Phase II Clinical Trial.

Document type:
Article; Journal Article
Author(s):
Multhoff, Gabriele; Seier, Sophie; Stangl, Stefan; Sievert, Wolfgang; Shevtsov, Maxim; Werner, Caroline; Pockley, A Graham; Blankenstein, Christiane; Hildebrandt, Martin; Offner, Robert; Ahrens, Norbert; Kokowski, Konrad; Hautmann, Matthias; Rödel, Claus; Fietkau, Rainer; Lubgan, Dorota; Huber, Rudolf; Hautmann, Hubert; Duell, Thomas; Molls, Michael; Specht, Hanno; Haller, Bernhard; Devecka, Michal; Sauter, Andreas; Combs, Stephanie E
Abstract:
PURPOSE: Non-small cell lung cancer (NSCLC) is a fatal disease with poor prognosis. A membrane-bound form of Hsp70 (mHsp70) which is selectively expressed on high-risk tumors serves as a target for mHsp70-targeting natural killer (NK) cells. Patients with advanced mHsp70-positive NSCLC may therefore benefit from a therapeutic intervention involving mHsp70-targeting NK cells. The randomized phase II clinical trial (EudraCT2008-002130-30) explores tolerability and efficacy of ex vivo-activated NK...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2020
Journal volume:
26
Journal issue:
20
Pages contribution:
5368-5379
Fulltext / DOI:
doi:10.1158/1078-0432.CCR-20-1141
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32873573
Print-ISSN:
1078-0432
TUM Institution:
Institut für Diagnostische und Interventionelle Radiologie; Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Kliniken und Institute
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