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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Won, Ki-Bum; Heo, Ran; Park, Hyung-Bok; Lee, Byoung Kwon; Lin, Fay Y; Hadamitzky, Martin; Kim, Yong-Jin; Sung, Ji Min; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J; Gottlieb, Ilan; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; de Araújo Gonçalves, Pedro; Leipsic, Jonathon A; Lee, Sang-Eun; Shin, Sanghoon; Choi, Jung Hyun; Virmani, Renu; Samady, Habib; Chinnaiyan, Kavitha; Berman, Daniel S; Narula, Jagat; Shaw, Leslee J; Bax, Jeroen J; Min, James K;...     »
Title:
Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors.
Abstract:
BACKGROUND AND AIMS: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma atherogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA). METHODS: A total of 1488 adults (60.9 ± 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concentrations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) ≥1.0%/year. All participants were divided into three groups based on AIP tertiles. RESULTS: Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02-2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV. CONCLUSIONS: Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.
Journal title abbreviation:
Atherosclerosis
Year:
2021
Journal volume:
324
Pages contribution:
46-51
Fulltext / DOI:
doi:10.1016/j.atherosclerosis.2021.03.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33813155
Print-ISSN:
0021-9150
TUM Institution:
Institut für Radiologie und Nuklearmedizin
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