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Title:

Circulating Interleukin-4 Is Associated with a Systemic T Cell Response against Tumor-Associated Antigens in Treatment-Naïve Patients with Resectable Non-Small-Cell Lung Cancer.

Document type:
Journal Article
Author(s):
Safi, Seyer; Yamauchi, Yoshikane; Hoffmann, Hans; Weichert, Wilko; Jost, Philipp J; Winter, Hauke; Muley, Thomas; Beckhove, Philipp
Abstract:
Spontaneous T cell responses to tumor-associated antigens (TAs) in the peripheral blood of patients with non-small-cell lung cancer (NSCLC) may be relevant for postoperative survival. However, the conditions underlying these T cell responses remain unclear. We quantified the levels of 27 cytokines in the peripheral blood and tumor tissues from treatment-naïve patients with NSCLC (n = 36) and analyzed associations between local and systemic cytokine profiles and both TA-specific T cell responses...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2020
Journal volume:
12
Journal issue:
12
Fulltext / DOI:
doi:10.3390/cancers12123496
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33255425
TUM Institution:
Chirurgische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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