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Titel:

Evidence of early increased sialylation of airway mucins and defective mucociliary clearance in CFTR-deficient piglets.

Dokumenttyp:
Article; Journal Article
Autor(en):
Caballero, Ignacio; Ringot-Destrez, Bélinda; Si-Tahar, Mustapha; Barbry, Pascal; Guillon, Antoine; Lantier, Isabelle; Berri, Mustapha; Chevaleyre, Claire; Fleurot, Isabelle; Barc, Céline; Ramphal, Reuben; Pons, Nicolas; Paquet, Agnès; Lebrigand, Kévin; Baron, Carole; Bähr, Andrea; Klymiuk, Nikolai; Léonard, Renaud; Robbe-Masselot, Catherine
Abstract:
BACKGROUND: Bacterial colonization in cystic fibrosis (CF) lungs has been directly associated to the loss of CFTR function, and/or secondarily linked to repetitive cycles of chronic inflammation/infection. We hypothesized that altered molecular properties of mucins could contribute to this process. METHODS: Newborn CFTR+/+ and CFTR-/- were sacrificed before and 6 h after inoculation with luminescent Pseudomonas aeruginosa into the tracheal carina. Tracheal mucosa and the bronchoalveolar lavage (...     »
Zeitschriftentitel:
J Cyst Fibros
Jahr:
2021
Band / Volume:
20
Heft / Issue:
1
Seitenangaben Beitrag:
173-182
Volltext / DOI:
doi:10.1016/j.jcf.2020.09.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32978064
Print-ISSN:
1569-1993
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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