Desch, Steffen; Freund, Anne; Akin, Ibrahim; Behnes, Michael; Preusch, Michael R; Zelniker, Thomas A; Skurk, Carsten; Landmesser, Ulf; Graf, Tobias; Eitel, Ingo; Fuernau, Georg; Haake, Hendrik; Nordbeck, Peter; Hammer, Fabian; Felix, Stephan B; Hassager, Christian; Engstrøm, Thomas; Fichtlscherer, Stephan; Ledwoch, Jakob; Lenk, Karsten; Joner, Michael; Steiner, Stephan; Liebetrau, Christoph; Voigt, Ingo; Zeymer, Uwe; Brand, Michael; Schmitz, Roland; Horstkotte, Jan; Jacobshagen, Claudius; Pöss, Janine; Abdel-Wahab, Mohamed; Lurz, Philipp; Jobs, Alexander; de Waha-Thiele, Suzanne; Olbrich, Denise; Sandig, Frank; König, Inke R; Brett, Sabine; Vens, Maren; Klinge, Kathrin; Thiele, Holger     «

Desch, Steffen; Freund, Anne; Akin, Ibrahim; Behnes, Michael; Preusch, Michael R; Zelniker, Thomas A; Skurk, Carsten; Landmesser, Ulf; Graf, Tobias; Eitel, Ingo; Fuernau, Georg; Haake, Hendrik; Nordbeck, Peter; Hammer, Fabian; Felix, Stephan B; Hassager, Christian; Engstrøm, Thomas; Fichtlscherer, Stephan; Ledwoch, Jakob; Lenk, Karsten; Joner, Michael; Steiner, Stephan; Liebetrau, Christoph; Voigt, Ingo; Zeymer, Uwe; Brand, Michael; Schmitz, Roland; Horstkotte, Jan; Jacobshagen, Claudius; Pöss,...     »

BACKGROUND: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest. However, the benefits of early coronary angiography and revascularization in resuscitated patients without electrocardiographic evidence of ST-segment elevation are unclear. METHODS: In this multicenter trial, we randomly assigned 554 patients with successfully resuscitated out-of-hospital cardiac arrest of possible coronary origin to undergo either immediate coronary angiography (immediate-angiography group) or initial intensive care assessment with delayed or selective angiography (delayed-angiography group). All the patients had no evidence of ST-segment elevation on postresuscitation electrocardiography. The primary end point was death from any cause at 30 days. Secondary end points included a composite of death from any cause or severe neurologic deficit at 30 days. RESULTS: A total of 530 of 554 patients (95.7%) were included in the primary analysis. At 30 days, 143 of 265 patients (54.0%) in the immediate-angiography group and 122 of 265 patients (46.0%) in the delayed-angiography group had died (hazard ratio, 1.28; 95% confidence interval [CI], 1.00 to 1.63; P = 0.06). The composite of death or severe neurologic deficit occurred more frequently in the immediate-angiography group (in 164 of 255 patients [64.3%]) than in the delayed-angiography group (in 138 of 248 patients [55.6%]), for a relative risk of 1.16 (95% CI, 1.00 to 1.34). Values for peak troponin release and for the incidence of moderate or severe bleeding, stroke, and renal-replacement therapy were similar in the two groups. CONCLUSIONS: Among patients with resuscitated out-of-hospital cardiac arrest without ST-segment elevation, a strategy of performing immediate angiography provided no benefit over a delayed or selective strategy with respect to the 30-day risk of death from any cause. (Funded by the German Center for Cardiovascular Research; TOMAHAWK ClinicalTrials.gov number, NCT02750462.).      «

BACKGROUND: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest. However, the benefits of early coronary angiography and revascularization in resuscitated patients without electrocardiographic evidence of ST-segment elevation are unclear. METHODS: In this multicenter trial, we randomly assigned 554 patients with successfully resuscitated out-of-hospital cardiac arrest of possible coronary origin to undergo either immediate coronary angiography (immediate-angiography group...     »